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Adipose drives insulin resistance.
Boss Tip Unlocked
More adipose tissue can release inflammation signals that blunt insulin’s effect — a key piece of the Ominous Octet called insulin resistance.
The good news: weight loss, nutrition, and movement can improve insulin sensitivity and bring sugars down (for many). If highs persist, other “octet” arms may still be at play — and we’ll tackle those next.
Inflammation ↑
Insulin sensitivity ↓
Lifestyle → Sensitivity ↑